This can lead to toxicity from these drugs. Cardizem may increase blood levels of buspirone, midazolam, triazolam, and diazepam by reducing their breakdown and elimination from the body by the liver.Cardizem increases blood levels of lovastatin, atorvastatin, and simvastatin, possibly increasing the risk of adverse effects.Similarly, concurrent administration of Cardizem with an anti- seizure medication, carbamazepine, can increase blood levels of the seizure medication, and occasionally lead to toxicity. worsening symptoms of heart failure when given to individuals with heart failure.ĭrug interactions of Cardizem include digoxin, which can increase digoxin blood levels.swelling of the legs and feet with fluid ( edema),.
Dilation of the arteries also reduces blood pressure. By reducing the heart's need for oxygen, Cardizem relieves or prevents angina. By dilating arteries, Cardizem reduces the pressure in the arteries into which the heart must pump blood, and, as a result, the heart needs to work less and requires less oxygen. The harder the heart works, the more oxygen it requires.Īngina occurs when the supply of oxygen to the heart is inadequate for the amount of work the heart must do. In order to pump blood, the heart needs oxygen. It also relaxes the muscles surrounding the arteries, allowing the arteries to widen (dilate). It is the entry of calcium into these cells that causes the cells to contract, allowing the heart to pump blood, and the arteries to narrow.īy blocking the entry of calcium, Cardizem decreases the force of contraction of the heart and its rate of contraction. Does Cardizem (diltiazem) cause side effects?Ĭardizem ( diltiazem) is a calcium channel blocker (CCB) used to treat heart pain ( angina), high blood pressure, and abnormal heart rhythms.ĬCBs block the entry of calcium into muscle cells that make up the heart and that surround the arteries.
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